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8 Things You Want to Know About Stem Cell Therapy

by in Stem Cell Database December 4, 2020

Previously, we had explained what are stem cells and why are they important. Stem cells can be guided into becoming specific cells that can be used to regenerate and repair diseased or damaged tissues in people. As a result, the potential of stem cells being used in treatment has been a subject of interest for doctors and scientists.

In this article, we will explain 8 things you want to know about stem cell therapy!

8 Things You Want to Know About Stem Cell Therapy

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1. What is stem cell therapy?

8 Things You Want to Know About Stem Cell Therapy

Image credit: 3283197d_273 from Getty Images

Stem cell therapy is a form of regenerative medicine designed to repair damaged cells within the body by reducing inflammation and modulating the immune system. This phenomenon makes stem cell therapy a viable treatment option for a variety of medical conditions.

Stem cell therapies have been used to treat autoimmune diseases, orthopaedic conditions, and traumatic injuries with studies conducted on use for Crohn’s disease, Multiple Sclerosis, Lupus, COPD, Parkinson’s, and more.

While stem cell therapy does not necessarily provide a cure for these conditions, the premise is to allow the body to heal itself well enough to mitigate the symptoms of the conditions for long periods. In many cases, this effect can substantially increase the quality of life for patients.

‍2. Where to obtain stem cells for treatment?

8 Things You Want to Know About Stem Cell Therapy

Image credit: Science Photo Library

Scientists can harvest stem cells in different ways. Stem cells can be obtained from many different sources. Embryonic stem cells come from umbilical cord tissue, placental tissue, umbilical cord blood. Adult stem cells are extracted from different types of tissue, such as adipose (fat tissue), the brain, blood vessels, skeletal muscle, or bone marrow.

Researchers grow stem cells in a lab. These stem cells are manipulated to specialize into specific types of cells, such as heart muscle cells, blood cells or nerve cells.

 

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‍3. How are stem cells administered?

Stem cells can be administered in a variety of fashions: IV Stem Cell Therapy (Intravenous administration), Intrathecal (directly into the spinal canal), site injections into problem areas (Knee, hips, hands, etc.)

‍4. How does stem cell therapy work?

8 Things You Want to Know About Stem Cell Therapy

Image credit: Olique from Getty Images

Stem cell therapy is a non-invasive treatment that aims to replace damaged cells within the body. Mesenchymal stem cell therapy can be deployed systemically via IV or injected locally to target specific sites, depending on patient needs.

Stem cells target inflammation

The therapeutic uses of stem cells as a potential therapy for a variety of diseases has been immensely explored, the number of clinical trials conducted with mesenchymal stem cells (MSCs) has increased exponentially over the past few years.

Stem cells have a unique, intrinsic property that attracts them to inflammation in the body. Studies have shown that stem cells can regenerate damaged or diseased tissues, reduce inflammation and modulate the immune system promoting better health and quality of life. Mesenchymal stem cells do this by influencing tissue repair via paracrine effects (cell signalling in order to change the behaviour of existing cells) or direct cell-to-cell contact.

5. How is stem cell therapy utilized?

8 Things You Want to Know About Stem Cell Therapy

Image credit: Pablo_K from Getty Images

Stem cell therapy may be able to treat orthopaedic conditions as well as autoimmune diseases, with studies conducted on use for Crohn’s Disease, Multiple Sclerosis, Lupus, COPD, Parkinson’s, and more.

Stem cells do not necessarily provide a cure for these conditions. The premise is allowing the body to heal itself well enough to mitigate the symptoms of the conditions for long periods. In many cases, this alone allows for a substantial increase in quality of life for patients.

 

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6. Have stem cells already been used to treat diseases?

Yes. Doctors have performed stem cell transplants, also known as bone marrow transplants.

In stem cell transplants, stem cells replace cells damaged by chemotherapy or disease or serve as a way for the donor’s immune system to fight some types of cancer and blood-related diseases, such as leukaemia, lymphoma, neuroblastoma and multiple myeloma. These transplants use adult stem cells or umbilical cord blood.

Researchers are testing adult stem cells to treat other conditions, including a number of degenerative diseases such as heart failure.

The potential use of stem cell. Image credit: Wikipedia

7. Will the body reject stem cells?

Cord-tissue derived mesenchymal stem cells do not have any risk of rejection within the body. They are youthful, immune-privileged, undifferentiated cells that have no rejection in the body because they have yet to be “claimed”.

There are no blood products associated with them either, removing the need for a donor match; they are universally accepted. These cells seek out inflammation in the body and begin to heal the damaged tissue. Mesenchymal cord tissue-derived stem cells have been administered thousands of times at clinics around the world without instances of rejection (graft vs. host disease).

 

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8 Things You Want to Know About Stem Cell Therapy

Image credit: Science Photo Library

8. Why use umbilical cord tissue?

Cord tissue is rich in mesenchymal stem cells, potentially used to help heal, regenerate & treat a variety of conditions. Mesenchymal stem cells derived from umbilical cord tissue have shown the ability to avoid a negative response from a person’s immune system, allowing the cells to be transplanted in a wide range of people without fear of rejection.

These transplants may have the ability to vastly increase the body’s natural healing abilities and have robust anti-inflammatory and immunosuppressive responses.

8 Things You Want to Know About Stem Cell Therapy

Umbilical cord tissue diagram showing where stem cells originate (Image credit: DVC Stem)

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Stem cells have played a groundbreaking role in treatment. Previously untreatable neurodegenerative diseases may now possibly become treatable with advanced stem cell therapies. Regenerative medicine and its benefits may be the key to prolonging human life, although more research may still be required.

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